Formamide and the origin of life

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چکیده

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Formamide and the origin of life.

The complexity of life boils down to the definition: "self-sustained chemical system capable of undergoing Darwinian evolution" (Joyce, 1994) [1]. The term "self-sustained" implies a set of chemical reactions capable of harnessing energy from the environment, using it to carry out programmed anabolic and catabolic functions. We briefly present our opinion on the general validity of this definit...

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Thermodynamics, formamide, and the origin of life: Comment on "Formamide and the origin of life" by R. Saladino et al.

“There is something rather than nothing because something is more stable”, wrote Victor Stenger about the universe [1]. The same applies to the origin of life; but what sort of something, and where? Thermodynamics and life itself are the surest guides. Thermodynamics, because life is more stable than non-life only under certain farfrom-equilibrium conditions. Life, because the best explanation ...

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A "warm formamide" scenario for the origins of life might not be so hot: Comment on "Formamide and the origin of life" by E. Di Mauro et al.

In this review, Saladino et al. present an intriguing hypothesis surrounding the role of formamide in the origins of life on Earth, backed by experimental results supporting each step from formamide to RNA polymers [1]. The overall premise is that, from formamide and inorganic phosphate, RNA molecules over 100 nucleotides in length can be produced. In addition, many carboxylic acids likely rele...

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ژورنال

عنوان ژورنال: Physics of Life Reviews

سال: 2012

ISSN: 1571-0645

DOI: 10.1016/j.plrev.2011.12.002